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Product Details
11519-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Symplekin Fusion Protein Ag2081 (118-478 aa encoded by BC006567)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTQLYKVAL QWMVKSRVIS ELQEACWDMV SAMAGDIILL LDSDNDGIRT HAIKFVEGLI VTLSPRMADS EIPRRQEHDI SLDRIPRDHP YIQYNVLWEE GKAALEQLLK FMVHPAISSI NLTTALGSLA NIARQRPMFM SEVIQAYETL HANLPPTLAK SQVSSVRKNL KLHLLSVLKH PASLEFQAQI TTLLVDLGTP QAEIARNMPS SKDTRKRPRD DSDSTLKKMK LEPNLGEDDE DKDLEPGPSG TSKASAQISG QSDTDITAEF LQPLLTPDNV ANLVLISMVY LPEAMPASFQ AIYTPVESAG TEAQIKHLAR LMATQMTAAG LGPGVEQTKQ CKEEPKEEKV VKTESVLIKR RL (118-478 aa encoded by BC006567)
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ27092; hepatocyte nuclear factor 3 gamma; Symplekin
Gene Aliases: 1500016F02Rik; 4632415H16Rik; AA125406; AI449890; Hfn3g; SPK; SYM; SYMPK
UniProt ID: (Human) Q92797, (Mouse) Q80X82
Entrez Gene ID: (Human) 8189, (Mouse) 68188, (Rat) 292683
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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