|Tested species reactivity||Bovine, Human, Mouse, Rat|
|Published species reactivity||Rat, Human, Mouse, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Purified bovine brain Synapsin 1|
|Purification||Antigen affinity chromatography|
|Storage buffer||5mM Ammonium bicarbonate|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||1 ug/200 ug rat brain lysate|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunocytochemistry (ICC)||See 2 publications below|
|Miscellaneous PubMed (MISC)||See 2 publications below|
|Western Blot (WB)||See 6 publications below|
|Immunofluorescence (IF)||See 1 publications below|
|Immunohistochemistry (IHC)||See 1 publications below|
|Immunohistochemistry (Frozen) (IHC (F))||See 1 publications below|
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Biophysical constraints of optogenetic inhibition at presynaptic terminals.
51-5200 was used in immunocytochemistry to study presynaptic terminals and biophyscial constraints of optogeneitc inhibition
|Mahn M,Prigge M,Ron S,Levy R,Yizhar O||Nature neuroscience (19:554)||2016|
iPSC Transplantation increases regeneration and functional recovery after ischemic stroke in neonatal rats.
51-5200 was used in immunocytochemistry to test if transplanted iPSC-derived neural progenitor cells increase regeneration after stroke in neonatal rats.
|Chau MJ,Deveau TC,Song M,Gu X,Chen D,Wei L||Stem cells (Dayton, Ohio) (32:3075)||2014|
Glimepiride protects neurons against amyloid-ß-induced synapse damage.
51-5200 was used in western blot to investigate how glimepiride protects neurons against synapse damage induced by Aβ.
|Osborne C,West E,Nolan W,McHale-Owen H,Williams A,Bate C||Neuropharmacology (101:225)||2016|
The progressive changes of filamentous actin cytoskeleton in the hippocampal neurons after pilocarpine-induced status epilepticus.
51-5200 was used in immunohistochemistry to assess the temporal and spatial changes of F-actin during the period of epileptogenesis
|Xiong T,Liu J,Dai G,Hou Y,Tan B,Zhang Y,Li S,Song Y,Liu H,Li Y,Li Y||Epilepsy research (118:55)||2015|
cAMP-Inhibits Cytoplasmic Phospholipase A¿ and Protects Neurons against Amyloid-ß-Induced Synapse Damage.
51-5200 was used in western blot to study Aβ-induced activation of cPLA.
|Bate C,Williams A||Biology (4:591)||2015|
Increased astrocyte expression of IL-6 or CCL2 in transgenic mice alters levels of hippocampal and cerebellar proteins.
51-5200 was used in western blot to study IL-6 and CCL2 in the central nervous system
|Gruol DL,Vo K,Bray JG||Frontiers in cellular neuroscience (8:null)||2014|
CCL2-ethanol interactions and hippocampal synaptic protein expression in a transgenic mouse model.
51-5200 was used in western blot to study the effect of ethanol exposure on CCL2 secretion and hippocampal synaptic protein expression
|Gruol DL,Vo K,Bray JG,Roberts AJ||Frontiers in integrative neuroscience (8:null)||2014|
Neurodegeneration induced by clustering of sialylated glycosylphosphatidylinositols of prion proteins.
51-5200 was used in western blot to study the impact of glycosylphosphatidylinositol anchoring on prion disease.
|Bate C,Williams A||The Journal of biological chemistry (287:7935)||2012|
|Mouse||1:5000||Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6.||Gruol DL,Puro A,Hao C,Blakely P,Janneke E,Vo K||Journal of neuroimmunology (239:28)||2011|
|Mouse||1:5000||Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced CCL2 expression.||Nelson TE,Hao C,Manos J,Ransohoff RM,Gruol DL||Brain, behavior, and immunity (25 Suppl 1:S106)||2011|
|Mouse||Not Cited||The rearrangement of filamentous actin in mossy fiber synapses in pentylenetetrazol-kindled C57BL/6 mice.||Zhang YF,Li SL,Xiong TQ,Yang LB,Li YN,Tan BH,Liu Q,Li YC||Epilepsy research (108:20)||2014|
Learning-related translocation of ¿-opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions.
51-5200 was used in immunohistochemistry to investigate the involvement of theta-opioid receptors in learning and the cognitive control of action
|Bertran-Gonzalez J,Laurent V,Chieng BC,Christie MJ,Balleine BW||The Journal of neuroscience : the official journal of the Society for Neuroscience (33:16060)||2013|
Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6.
51-5200 was used in immunohistochemistry - frozen section to assess the role of IL-6 in neuronal function.
|Nelson TE,Olde Engberink A,Hernandez R,Puro A,Huitron-Resendiz S,Hao C,De Graan PN,Gruol DL||Brain, behavior, and immunity (26:959)||2012|