Recommended positive controls: human brain, mouse brain, rat brain, Mouse small intestine, LNCaP.
Predicted reactivity: Mouse (94%), Rat (95%), Rhesus Monkey (97%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BM89 antigen; Major synaptic vesicle protein p38; Synaptophysin; Syp I
Gene Aliases: A230093K24Rik; AI848995; MRX96; MRXSYP; p38; Syn; SYP; Syp1