Proteintech

Synaptopodin Polyclonal Antibody

Synaptopodin Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

Synaptopodin Antibody (21064-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using SYNPO antibody 21064-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Synaptopodin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Synaptopodin Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Synaptopodin Antibody in Western Blot (WB)

Product Image Gallery

Product Details

21064-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 21 publications 21 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 25 publications 25 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synaptopodin Fusion Protein Ag15089 (580-929 aa encoded by BC146665)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SPPSYSVLY PSSDPKSSHL KGQAVPASKT GILEESMARR GSRKSMFTFV EKPKVTPNPD LLDLVQTADE KRRQRDQGEV GVEEEPFALG AEASNFQQEP APRDRASPAA AEEVVPEWAS CLKSPRIQAK PKPKPNQNLS EASGKGAELY ARRQSRMEKY VIESSSHTPE LARCPSPTMS LPSSWKYPTN APGAFRVASR SPARTPPASL YHGYLPENGV LRPEPTKQPP YQLRPSLFVL SPIKEPAKVS PRAASPAKPS SLDLVPNLPK GALPPSPALP RPSRSSPGLY TSPGQDSLQP TAVSPPYGGD ISPVSPSRAW SPRAKQAPRP SFSTRNAGIE AQVWKPSFCF K (580-929 aa encoded by BC146665)

Target Information

SYNPO (Synaptopodin) is an actin-associated protein in telencephalic dendrites and renal podocytes. SYNPO is tightly associated with the dendritic spine apparatus, and mice lacking the SYNPO gene lack the apparatus. These SYNPO-null mice also demonstrate an impaired ability to express long-term potentiation as well as deficits in spatial memory tasks, indicating that SYNPO is involved in the regulation of synaptic plasticity. Recent studies suggest that SYNPO is linked to neuronal calcium stores and plays a role in the calcium store-associated ability of neurons to undergo long-term plasticity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Identification of circular dorsal ruffles as signal platforms for the AKT pathway in glomerular podocytes.

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WT1⁺ glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.

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Hong X,Nie H,Deng J,Liang S,Chen L,Li J,Gong S,Wang G,Zuo W,Hou F,Zhang F

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WT1⁺ glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.

Theranostics

Hong X,Nie H,Deng J,Liang S,Chen L,Li J,Gong S,Wang G,Zuo W,Hou F,Zhang F

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Molecular genetics & genomic medicine

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Wang Z,Chang Y,Liu Y,Liu B,Zhen J,Li X,Lin J,Yu Q,Lv Z,Wang R

Tue Jun 14 00:00:00 UTC 2022

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Molecular therapy. Nucleic acids

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Tue Jun 14 00:00:00 UTC 2022

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ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.

International immunopharmacology

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Molecular and cellular endocrinology

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Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.

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Tue Jun 01 00:00:00 UTC 2021

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Experimental cell research

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Wed Jan 20 00:00:00 UTC 2021

Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.

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Wang S,Yang Y,He X,Yang L,Wang J,Xia S,Liu D,Liu S,Yang L,Liu W,Duan H

Wed Jan 20 00:00:00 UTC 2021

Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.

Antioxidants & redox signaling

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Wed Jan 20 00:00:00 UTC 2021

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Experimental cell research

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.

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Wed Dec 04 00:00:00 UTC 2019

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Cell death & disease

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Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H

Sun Sep 01 00:00:00 UTC 2019

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H

Sun Sep 01 00:00:00 UTC 2019

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

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Sun Sep 01 00:00:00 UTC 2019

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Thu Aug 30 00:00:00 UTC 2018

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.

Development (Cambridge, England)

Menon R,Otto EA,Kokoruda A,Zhou J,Zhang Z,Yoon E,Chen YC,Troyanskaya O,Spence JR,Kretzler M,Cebrián C

Thu Aug 30 00:00:00 UTC 2018

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Life sciences

Ma Q,Wang Y,Zhang T,Zuo W

Mon Jan 15 00:00:00 UTC 2018

Notch-mediated Sox9⁺ cell activation contributes to kidney repair after partial nephrectomy.

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Mon Jan 15 00:00:00 UTC 2018

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Medical science monitor : international medical journal of experimental and clinical research

Wang Y,Li Y,Zhang T,Chi Y,Liu M,Liu Y

Thu Jul 12 00:00:00 UTC 2018

Genistein and Myd88 Activate Autophagy in High Glucose-Induced Renal Podocytes In Vitro.

Medical science monitor : international medical journal of experimental and clinical research

Wang Y,Li Y,Zhang T,Chi Y,Liu M,Liu Y

Thu Jul 12 00:00:00 UTC 2018

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.

Lab on a chip

Wang L,Tao T,Su W,Yu H,Yu Y,Qin J

Tue May 16 00:00:00 UTC 2017

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.

Lab on a chip

Wang L,Tao T,Su W,Yu H,Yu Y,Qin J

Tue May 16 00:00:00 UTC 2017

Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.

Journal of diabetes research

Lv Z,Hu M,Ren X,Fan M,Zhen J,Chen L,Lin J,Ding N,Wang Q,Wang R

Tue Dec 20 00:00:00 UTC 2016

Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.

Journal of diabetes research

Lv Z,Hu M,Ren X,Fan M,Zhen J,Chen L,Lin J,Ding N,Wang Q,Wang R

Tue Dec 20 00:00:00 UTC 2016

Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.

Biochimica et biophysica acta

Gao P,Meng XF,Su H,He FF,Chen S,Tang H,Tian XJ,Fan D,Wang YM,Liu JS,Zhu ZH,Zhang C

Sat Nov 01 00:00:00 UTC 2014

Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.

Biochimica et biophysica acta

Gao P,Meng XF,Su H,He FF,Chen S,Tang H,Tian XJ,Fan D,Wang YM,Liu JS,Zhu ZH,Zhang C

Sat Nov 01 00:00:00 UTC 2014

Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.

Life sciences

Wang Z,Liu J,Sun W

Tue Sep 03 00:00:00 UTC 2013

Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.

Life sciences

Wang Z,Liu J,Sun W

Tue Sep 03 00:00:00 UTC 2013

Noninvasive urine-derived cell lines derived from neurological genetic patients.

Neuroreport

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Wed Mar 06 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Synaptopodin

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Gene Aliases: 9030217H17Rik; 9130229N11; 9330140I15Rik; AW046661; KIAA1029; SYNPO

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UniProt ID: (Human) Q8N3V7, (Rat) Q9Z327

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Entrez Gene ID: (Human) 11346, (Rat) 60324, (Mouse) 104027

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Function(s)

actin binding protein binding actin or actin-binding cytoskeletal protein

Process(es)

positive regulation of actin filament bundle assembly regulation of stress fiber assembly cortical cytoskeleton organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Synaptopodin Polyclonal Antibody

Synaptopodin Antibody (21064-1-AP) in ICC/IF

Product Details

21064-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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