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Product Details
13646-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Syntaphilin Fusion Protein Ag4594 (121-424 aa encoded by BC035788)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WIEEECHRV EAQLALKEAR KEIKQLKQVI DTVKNNLIDK DKGLQKYFVD INIQNKKLET LLHSMEVAQN GMAKEDGTGE SAGGSPARSL TRSSTYTKLS DPAVCGDRQP GDPSSGSAED GADSGFAAAD DTLSRTDALE ASSLLSSGVD CGTEETSLHS SFGLGPRFPA SNTYEKLLCG MEAGVQASCM QERAIQTDFV QYQPDLDTIL EKVTQAQVCG TDPESGDRCP ELDAHPSGPR DPNSAVVVTV GDELEAPEPI TRGPTPQRPG ANPNPGQSVS VVCPMEEEEE AAVAEKEPKS YWSRH (121-424 aa encoded by BC035788)
Target Information
Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bA314N13.5; Syntaphilin
Gene Aliases: 6430515A01; AW045671; AW556958; AW743098; KIAA0374; mKIAA0374; SNPH
UniProt ID: (Human) O15079, (Rat) B5DF41, (Mouse) Q80U23
Entrez Gene ID: (Human) 9751, (Rat) 296267, (Mouse) 241727
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