This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
PA1-1042 detects Syntaxin 1 in rat, mouse and bovine samples.
PA1-1042 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~33 kDa protein representing Syntaxin 1 in rat, mouse and bovine brain tissue samples.
The PA1-1042 immunogen is a synthetic peptide corresponding to residues V(22) T V D R D R F M D E F F E Q V E E I R(41) of rat Syntaxin 1. This sequence is conserved in mouse, human and bovine. The PA1-1042 immunizing peptide (Cat. # PEP-278) is available for use in neutralization and control experiments.
Syntaxin 1 is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells and thought to be implicated in the regulation of synaptic neurotransmitter release.
Syntaxin 1 interacts with several other proteins important for synaptic function (SNAP 25, Munc 18). Syntaxin 1 is the main target of one of the Botulinum neurotoxins (BoNT/C1) which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex.
Syntaxin 1 is an essential component of the neurotransmitter release machinery, and regulation of Syntaxin 1 expression levels is thought to contribute to the mechanism underlying learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HPC-1; Neuron-specific antigen HPC-1; P35-1; P35A; STX1; SYN1A; Synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A (brain); syntaxin 1A (brain)-like; Syntaxin-1A
Gene Aliases: BOS_23037; HPC-1; P35-1; Sap; STX1; STX1A; SYN1A