Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Marmoset, Mouse, Rat, Hamster, Pig, Xenopus (100%).
Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Neuron-specific antigen HPC-1; STX1B; STX1B1; STX1B2; STXA1; syntaxin 1A (brain); Syntaxin-1A
Gene Aliases: HPC-1; P35-1; STX1; STX1A; SYN1A
UniProt ID: (Human) Q16623
Entrez Gene ID: (Human) 6804
Molecular Function: SNARE protein