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Syntaxin 11 Polyclonal Antibody

View all (8) STX11 antibodies

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Syntaxin 11 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using (Product # 13301-1-AP) (Syntaxin 11 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Syntaxin 11 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lymphoma using 13301-1-AP (Syntaxin 11 antibody) at dilution of 1:100 (under 10x lens).

Syntaxin 11 Antibody in Western Blot (WB) — Human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 13301-1-AP (Syntaxin 11 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Syntaxin 11 Antibody in Western Blot (WB) — Human placenta tissue were subjected to SDS PAGE followed by western blot with 13301-1-AP (Syntaxin 11 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

Syntaxin 11 Antibody in Western Blot (WB) — Mouse lung tissue were subjected to SDS PAGE followed by western blot with 13301-1-AP (Syntaxin 11 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Syntaxin 11 Antibody in Western Blot (WB) — DU 145 cells were subjected to SDS PAGE followed by western blot with 13301-1-AP (Syntaxin 11 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Syntaxin 11 Antibody in Western Blot (WB) — Jurkat cells were subjected to SDS PAGE followed by western blot with 13301-1-AP (Syntaxin 11 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Syntaxin 11 Antibody in Western Blot (WB) — L02 cells were subjected to SDS PAGE followed by western blot with 13301-1-AP (Syntaxin 11 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Product Details

13301-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 7 publications 7 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunocytochemistry (ICC/IF)	-	View 2 publications 2 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Syntaxin 11 Fusion Protein Ag4097 (1-287 aa encoded by BC033519) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.35 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MKDRLAELL DLSKQYDQQF PDGDDEFDSP HEDIVFETDH ILESLYRDIR DIQDENQLLV ADVKRLGKQN ARFLTSMRRL SSIKRDTNSI AKAIKARGEV IHCKLRAMKE LSEAAEAQHG PHSAVARISR AQYNALTLTF QRAMHDYNQA EMKQRDNCKI RIQRQLEIMG KEVSGDQIED MFEQGKWDVF SENLLADVKG ARAALNEIES RHRELLRLES RIRDVHELFL QMAVLVEKQA DTLNVIELNV QKTVDYTGQA KAQVRKAVQY EEKNPCRTLC CFCCPCLK (1-287 aa encoded by BC033519)

Target Information

This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.

Frontiers in immunology

Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

Fri May 10 00:00:00 EDT 2019

C2 Domains of Munc13-4 Are Crucial for Ca²⁺-Dependent Degranulation and Cytotoxicity in NK Cells.

Journal of immunology (Baltimore, Md. : 1950)

Bin NR,Ma K,Tien CW,Wang S,Zhu D,Park S,Turlova E,Sugita K,Shirakawa R,van der Sluijs P,Horiuchi H,Sun HS,Monnier PP,Gaisano HY,Sugita S

Sun Jul 15 00:00:00 EDT 2018

Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.

PloS one

Hellewell AL,Foresti O,Gover N,Porter MY,Hewitt EW

Mon Jun 15 00:00:00 EDT 2015

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

Journal of cell science

Bin NR,Jung CH,Kim B,Chandrasegram P,Turlova E,Zhu D,Gaisano HY,Sun HS,Sugita S

Fri May 15 00:00:00 EDT 2015

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

Journal of cell science

Bin NR,Jung CH,Kim B,Chandrasegram P,Turlova E,Zhu D,Gaisano HY,Sun HS,Sugita S

Fri May 15 00:00:00 EDT 2015

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 EDT 2014

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Proceedings of the National Academy of Sciences of the United States of America

Bin NR,Jung CH,Piggott C,Sugita S

Tue Mar 19 00:00:00 EDT 2013

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Proceedings of the National Academy of Sciences of the United States of America

Bin NR,Jung CH,Piggott C,Sugita S

Tue Mar 19 00:00:00 EDT 2013

Effect of glucocorticoid on the biosynthesis of growth hormone-containing secretory granules in pituitary cells.

Biochemical and biophysical research communications

Kawashima R,Ikematsu K,Abe Y,Sato M,Tsuruya S,Nakasono I,Fukushima H,Inoue K,Tsuboi T

Fri Sep 17 00:00:00 EDT 2010

STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.

Pediatric blood & cancer

Marsh RA,Satake N,Biroschak J,Jacobs T,Johnson J,Jordan MB,Bleesing JJ,Filipovich AH,Zhang K

Thu Jul 15 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: Syntaxin-11

Gene Aliases: 5830405C08Rik; FHL4; HLH4; HPLH4; STX11

UniProt ID: (Human) O75558, (Mouse) Q9D3G5

Entrez Gene ID: (Human) 8676, (Mouse) 74732, (Rat) 292483

Molecular Function: SNARE protein

intracellular protein transport synaptic vesicle fusion to presynaptic active zone membrane vesicle docking membrane fusion T cell mediated cytotoxicity transport protein transport vesicle-mediated transport natural killer cell mediated cytotoxicity neutrophil degranulation cytotoxic T cell degranulation natural killer cell degranulation

Process(es)

SNARE binding SNAP receptor activity protein binding