Proteintech

Syntaxin 4 Polyclonal Antibody

View all (13) Syntaxin 4 antibodies

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Questions & Answers

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Syntaxin 4 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 14988-1-AP (Syntaxin 4 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

Syntaxin 4 Antibody in Western Blot (WB) — Rat kidney tissue were subjected to SDS PAGE followed by western blot with 14988-1-AP (Syntaxin 4 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

Syntaxin 4 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with 14988-1-AP (Syntaxin 4 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours.

Syntaxin 4 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 14988-1-AP (Syntaxin 4 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

Syntaxin 4 Antibody in Western Blot (WB) — Jurkat cells were subjected to SDS PAGE followed by western blot with 14988-1-AP (Syntaxin 4 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

Syntaxin 4 Antibody in Immunoprecipitation (IP) — IP result of anti-Syntaxin 4 (IP:14988-1-AP, 4ug; Detection:14988-1-AP 1:1500) with mouse kidney tissue lysate 4000ug.

Product Details

14988-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Syntaxin 4 Fusion Protein Ag6973 (1-272 aa encoded by BC002436)

Conjugate

Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: MRDRTHELR QGDDSSDEED KERVALVVHP GTARLGSPDE EFFHKVRTIR QTIVKLGNKV QELEKQQVTI LATPLPEESM KQELQNLRDE IKQLGREIRL QLKAIEPQKE EADENYNSVN TRMRKTQHGV LSQQFVELIN KCNSMQSEYR EKNVERIRRQ LKITNAGMVS DEELEQMLDS GQSEVFVSNI LKDTQVTRQA LNEISARHSE IQQLERSIRE LHDIFTFLAT EVEMQGEMIN RIEKNILSSA DYVERGQEHV KTALENQKKA RKK (1-272 aa encoded by BC002436)

Target Information

STX4 is a plasma membrane t-SNARE that mediates docking of transport vesicles.STX4 is necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, STX4 may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. STX4 may also play a role in docking of synaptic vesicles at presynaptic active zones.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Angiopoietin2-mediated caveolin1 phosphorylation regulating transcytosis of renal tubular epithelial cell contributes to the occurrence of albuminuria under high glucose exposure.

Journal of translational medicine

Liu J,Yao J,Zhao Y,Su J,Ye J,Wang Y

Mon Apr 25 00:00:00 EDT 2022

PKCε controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode.

International journal of biological macromolecules

Serrano-López EM,López-Martínez D,Gómez-Fernández JC,Egea-Jiménez AL,Corbalán-García S

Tue Aug 31 00:00:00 EDT 2021

Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction.

Brain : a journal of neurology

Yu Z,Shi M,Stewart T,Fernagut PO,Huang Y,Tian C,Dehay B,Atik A,Yang D,De Giorgi F,Ichas F,Canron MH,Ceravolo R,Frosini D,Kim HJ,Feng T,Meissner WG,Zhang J

Mon Jun 01 00:00:00 EDT 2020

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Neuroscience

Duan XL,Guo Z,He YT,Li YX,Liu YN,Bai HH,Li HL,Hu XD,Suo ZW

Sun Mar 01 00:00:00 EST 2020

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.

Frontiers in immunology

Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

Fri May 10 00:00:00 EDT 2019

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.

Frontiers in immunology

Lopez JA,Noori T,Minson A,Li Jovanoska L,Thia K,Hildebrand MS,Akhlaghi H,Darcy PK,Kershaw MH,Brown NJ,Grigg A,Trapani JA,Voskoboinik I

Fri May 10 00:00:00 EDT 2019

Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.

The Journal of biological chemistry

Aerbajinai W,Liu L,Zhu J,Kumkhaek C,Chin K,Rodgers GP

Fri Apr 15 00:00:00 EDT 2016

Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.

The Journal of biological chemistry

Aerbajinai W,Liu L,Zhu J,Kumkhaek C,Chin K,Rodgers GP

Fri Apr 15 00:00:00 EDT 2016

C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells.

British journal of pharmacology

Bian F,Yang X,Zhou F,Wu PH,Xing S,Xu G,Li W,Chi J,Ouyang C,Zhang Y,Xiong B,Li Y,Zheng T,Wu D,Chen X,Jin S

Thu May 01 00:00:00 EDT 2014

C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells.

British journal of pharmacology

Bian F,Yang X,Zhou F,Wu PH,Xing S,Xu G,Li W,Chi J,Ouyang C,Zhang Y,Xiong B,Li Y,Zheng T,Wu D,Chen X,Jin S

Thu May 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Renal carcinoma antigen NY-REN-31; syntaxin 4A (placental); Syntaxin-4

Gene Aliases: p35-2; STX4; STX4A; Syn-4; Syn4

UniProt ID: (Human) Q12846, (Rat) Q08850, (Mouse) P70452

Entrez Gene ID: (Human) 6810, (Rat) 81803, (Mouse) 20909

Molecular Function: SNARE protein

intracellular protein transport post-Golgi vesicle-mediated transport positive regulation of cell proliferation regulation of exocytosis positive regulation of cell migration synaptic vesicle fusion to presynaptic active zone membrane response to hydroperoxide SNARE complex assembly positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of catalytic activity positive regulation of eosinophil degranulation positive regulation of cell adhesion vesicle docking organelle fusion positive regulation of chemotaxis positive regulation of immunoglobulin secretion long-term synaptic potentiation positive regulation of establishment of protein localization to plasma membrane regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein localization to plasma membrane positive regulation of protein localization to cell surface protein complex assembly synaptic vesicle docking intracellular transport membrane fusion transport neurotransmitter transport synaptic vesicle exocytosis vesicle-mediated transport

Process(es)

SNARE binding SNAP receptor activity protein binding sphingomyelin phosphodiesterase activator activity myosin binding Rab GTPase binding spectrin binding