Syntaxin 6 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. Syntaxin is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: HGNC:11441; Syn6; Syntaxin-6
Gene Aliases: 2310039E05Rik; 2410005I16Rik; AA437559; AI415714; AI845861; STX6
Molecular Function: SNARE protein