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OriGene

CD4 Monoclonal Antibody (OTI10B5), TrueMAB™

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View all (491) CD4 antibodies

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CD4 Monoclonal Antibody (OTI10B5), TrueMAB™

Product Details

TA500477

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Dog, Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI10B5

Immunogen

Full length human recombinant protein of human CD4 produced in HEK293T cell.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; cd4a; fCD4; Leu-3; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T4 surface glycoprotein precursor; unnamed protein product; W3/25 antigen

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Gene Aliases: CD4; CD4mut; IMD79; Leu-3; OKT4D; p55; T4; W3/25

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UniProt ID: (Dog) P33705, (Human) P01730, (Rat) P05540

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Entrez Gene ID: (Dog) 403931, (Human) 920, (Rat) 24932

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Function(s)
zinc ion binding coreceptor activity interleukin-16 binding interleukin-16 receptor activity protein homodimerization activity virus receptor activity transmembrane signaling receptor activity receptor binding extracellular matrix structural constituent protein binding lipid binding immunoglobulin binding enzyme binding protein kinase binding MHC class II protein complex binding signaling receptor activity MHC class II protein binding identical protein binding protein tyrosine kinase binding glycoprotein binding
Process(es)
cytokine production induction by virus of host cell-cell fusion immune response cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation adaptive immune response cell adhesion macrophage differentiation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell regulation of calcium ion transport cellular response to granulocyte macrophage colony-stimulating factor stimulus positive regulation of protein phosphorylation immune system process positive regulation of immune system process signal transduction enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of calcium ion transport into cytosol calcium-mediated signaling response to estradiol positive regulation of interleukin-2 production response to vitamin D positive regulation of kinase activity helper T cell enhancement of adaptive immune response interleukin-15-mediated signaling pathway positive regulation of T cell proliferation positive regulation of MAPK cascade response to ethanol viral entry into host cell positive regulation of multicellular organismal process positive regulation of ERK1 and ERK2 cascade response to methamphetamine hydrochloride cellular response to ionomycin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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