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OriGene
IGF2BP2 Monoclonal Antibody (OTI3F9), TrueMAB™
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Product Details
TA501269
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3F9
Immunogen
Full length human recombinant protein of human IGF2BP2 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
IGF2BP2 is a member of the IGF-II mRNA-binding protein (IMP) family. It recruits target transcripts to cytoplasmic protein-RNA complexes. The protein contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IGF2BP2; RNA-binding protein; Insulin-like growth factor 2 mRNA-binding protein 2; p62; unnamed protein product; VICKZ family member 2
Gene Aliases: IGF2BP2; IMP-2; IMP2; VICKZ2
UniProt ID: (Human) Q9Y6M1
Entrez Gene ID: (Dog) 478662, (Human) 10644
regulation of cytokine production
regulation of translation
nervous system development
anatomical structure morphogenesis
negative regulation of translation
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
RNA stabilization
mRNA transport
CRD-mediated mRNA stabilization
energy homeostasis
cold-induced thermogenesis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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