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OriGene
LDLRAP1 Monoclonal Antibody (OTI4B10), TrueMAB™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
TA503846
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4B10
Immunogen
Full length human recombinant protein of human LDLRAP1 produced in HEK293T cell.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.62 mg/mL
Amount
62 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: autosomal recessive hypercholesterolemia protein; DKFZp586D0624; LDL receptor adaptor protein; MGC34705; RP11-70P17.2; unnamed protein product
Gene Aliases: ARH; ARH1; ARH2; FHCB1; FHCB2; FHCL4
UniProt ID: (Human) Q5SW96
Entrez Gene ID: (Human) 26119
beta-amyloid binding
phosphotyrosine binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
receptor signaling complex scaffold activity
clathrin binding
signaling adaptor activity
AP-2 adaptor complex binding
clathrin adaptor activity
AP-1 adaptor complex binding
low-density lipoprotein particle receptor binding
receptor-mediated endocytosis
cholesterol metabolic process
cholesterol transport
receptor internalization
low-density lipoprotein particle clearance
cholesterol homeostasis
amyloid precursor protein metabolic process
regulation of protein binding
positive regulation of receptor-mediated endocytosis
cellular response to cytokine stimulus
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
positive regulation of cholesterol metabolic process
regulation of protein localization to plasma membrane
positive regulation of vascular smooth muscle cell proliferation
positive regulation of low-density lipoprotein particle clearance
positive regulation of receptor-mediated endocytosis involved in cholesterol transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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