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OriGene
NEUROG1 Monoclonal Antibody (OTI9A8), Biotin, TrueMAB™
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Product Details
TA700005
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI9A8
Immunogen
Full length human recombinant protein of human NEUROG1 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 10mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa6; Class A basic helix-loop-helix protein 6; NeuroD3; Neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; Neurogenic differentiation factor 3; Neurogenin-1; NGN-1; unnamed protein product
Gene Aliases: AKA; BHLHA6; CCDDRD; Math4C; NEUROD3; NEUROG1; NGN; NGN1
UniProt ID: (Human) Q92886
Entrez Gene ID: (Human) 4762
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
protein dimerization activity
E-box binding
sequence-specific double-stranded DNA binding
regulation of transcription from RNA polymerase II promoter
thorax and anterior abdomen determination
nervous system development
sensory organ development
exit from mitosis
trigeminal nerve development
vestibulocochlear nerve formation
neurogenesis
cell differentiation
neuron differentiation
peristalsis
forebrain development
auditory behavior
positive regulation of exit from mitosis
genitalia morphogenesis
inner ear morphogenesis
cell fate commitment
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of muscle organ development
genitalia development
inner ear development
neuromuscular process controlling balance
positive regulation of sequence-specific DNA binding transcription factor activity
axon development
mastication
cochlea development
cochlea morphogenesis
craniofacial suture morphogenesis
learned vocalization behavior
negative regulation of relaxation of muscle
negative regulation of saliva secretion
hard palate morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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