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OriGene
CHEK2 Monoclonal Antibody (OTI4C10), Biotin, TrueMAB™
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Product Details
TA700006
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4C10
Immunogen
Full length human recombinant protein of human CHEK2 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 10mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in CHK2 are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cds1; Cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; checkpoint-like protein CHK2; CHEK2; Chk2 (phospho T68); Chk2 (pThr68); CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); Chk2 phospho; Chk2 phospho T68; Chk2-del2-12; Chk2-del2-3; Chk2-del4; Chk2-del7; Chk2-del9; Chk2-del9-12; Chk2-insX; Chk2-insZ; Chk2-iso1; Chk2-iso2; Chk2-sub3; contains FHA domain; del9; EC 2.7.11.1; HuCds 1; Hucds1; kinase Chk2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199064; OTTHUMP00000199115; OTTHUMP00000199116; phospho Chk2 (T68); phospho Thr68 Chk2; RP11-436C9.1; Serine/threonine protein kinase Chk2; Serine/threonine-protein kinase Chk2; unnamed protein product
Gene Aliases: CDS1; CHEK2; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53; TPDS4
UniProt ID: (Human) O96017
Entrez Gene ID: (Human) 11200
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding
protein serine kinase activity
autophagosome assembly
DNA damage checkpoint
G2/M transition of mitotic cell cycle
DNA repair
double-strand break repair
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
protein catabolic process
DNA damage response, signal transduction by p53 class mediator
intra-S DNA damage checkpoint
cellular response to stress
regulation of protein catabolic process
response to starvation
signal transduction in response to DNA damage
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
mitotic DNA damage checkpoint
positive regulation of transcription, DNA-templated
protein autophosphorylation
protein stabilization
cell division
thymocyte apoptotic process
protein K63-linked ubiquitination
cellular response to xenobiotic stimulus
cellular response to gamma radiation
mitotic spindle assembly
replicative senescence
regulation of signal transduction by p53 class mediator
response to glycoside
cellular response to bisphenol A
negative regulation of DNA damage checkpoint
positive regulation of anoikis
regulation of autophagosome assembly
positive regulation of autophagosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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