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OriGene
PRKCE Monoclonal Antibody (OTI1B4), Biotin, TrueMAB™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
TA700070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1B4
Immunogen
Full length human recombinant protein of human PRKCE produced in HEK293T cell
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 10mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The PKC family of serine/threonine kinases, including PRKCE (PKC epsilon), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC125656; MGC125657; PKC e; unnamed protein product
Gene Aliases: nPKC-epsilon; PKCE
UniProt ID: (Human) Q02156
Entrez Gene ID: (Human) 5581
actin monomer binding
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
calcium-independent protein kinase C activity
protein binding
ATP binding
enzyme activator activity
enzyme binding
receptor activator activity
ethanol binding
14-3-3 protein binding
protein serine kinase activity
apoptotic process
signal transduction
toxin catabolic process
positive regulation of epithelial cell migration
positive regulation of fibroblast migration
regulation of metal ion transport
positive regulation of actin filament polymerization
negative regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of cytokinesis
positive regulation of superoxide anion generation
regulation of actin cytoskeleton organization
intracellular signal transduction
TRAM-dependent toll-like receptor 4 signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
xenobiotic catabolic process
positive regulation of wound healing
negative regulation of sodium ion transmembrane transport
positive regulation of protein localization to plasma membrane
regulation of cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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