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OriGene
S100B Monoclonal Antibody (OTI3G6), Biotin, TrueMAB™
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Product Details
TA700560
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3G6
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human S100B (NP_006263).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol, 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Dilute in PBS (pH7.3) if necessary. Stable for 12 months from date of receipt.
Target Information
S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein S100-B; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium binding protein beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein, beta (neural); S100 protein beta chain; S100B
Gene Aliases: NEF; S100; S100-B; S100B; S100beta
UniProt ID: (Human) P04271
Entrez Gene ID: (Human) 6285
cell adhesion
axonogenesis
central nervous system development
learning or memory
memory
positive regulation of cell proliferation
regulation of cell shape
positive regulation of myelination
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of neuron differentiation
regulation of neuronal synaptic plasticity
astrocyte differentiation
positive regulation of synaptic transmission
response to glucocorticoid
response to methylmercury
long-term synaptic potentiation
cellular response to hypoxia
response to anesthetic
sympathetic neuron projection extension
neuron projection extension
adaptive thermogenesis
negative regulation of skeletal muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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