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OriGene
PIK3CA Monoclonal Antibody (OTI6D9), TrueMAB™
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Product Details
TA801592
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI6D9
Immunogen
Human recombinant protein fragment corresponding to amino acids 303-631 of human PIK3CA produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K alpha; pi3kca; PIK3R1; pk3ca; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA; unnamed protein product
Gene Aliases: CCM4; CLAPO; CLOVE; CWS5; HMH; MCAP; MCM; MCMTC; p110-alpha; PI3K; PI3K-alpha; PIK3CA
UniProt ID: (Human) P42336
Entrez Gene ID: (Human) 5290
nucleotide binding
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
1-phosphatidylinositol-3-kinase activity
transferase activity
protein kinase activator activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
insulin receptor substrate binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein serine kinase activity
angiogenesis
liver development
vasculature development
glucose metabolic process
lipid metabolic process
phagocytosis
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
regulation of gene expression
positive regulation of lamellipodium assembly
negative regulation of gene expression
response to activity
response to muscle inactivity
negative regulation of macroautophagy
cell migration
actin cytoskeleton organization
platelet activation
negative regulation of actin filament depolymerization
positive regulation of TOR signaling
cellular response to insulin stimulus
response to muscle stretch
phosphatidylinositol-3-phosphate biosynthetic process
vascular endothelial growth factor signaling pathway
regulation of multicellular organism growth
response to leucine
anoikis
regulation of cellular respiration
protein kinase B signaling
negative regulation of neuron apoptotic process
endothelial cell migration
phosphatidylinositol phosphorylation
insulin-like growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
positive regulation of protein kinase B signaling
relaxation of cardiac muscle
cardiac muscle contraction
adipose tissue development
cellular response to glucose stimulus
cellular response to hydrostatic pressure
response to dexamethasone
cardiac muscle cell contraction
energy homeostasis
regulation of actin filament organization
autosome genomic imprinting
response to butyrate
positive regulation of protein localization to membrane
negative regulation of fibroblast apoptotic process
negative regulation of anoikis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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