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OriGene
EPO Monoclonal Antibody (OTI5D8), TrueMAB™
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FIGURE: 1 / 1
EPO Antibody (TA812059) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY EPO (RC210775, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-EPO. (1:5. Positive lysates LY400277 (100 µg) and LC400277 (20 µg) can be purchased separately from OriGene.
Product Details
TA812059
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5D8
Immunogen
Human recombinant protein fragment corresponding to amino acids 28-193 of human EPO produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epoetin; Erythropoietin; MGC138142; unnamed protein product
Gene Aliases: DBAL; ECYT5; EP; EPO; MVCD2
UniProt ID: (Human) P01588
Entrez Gene ID: (Human) 2056
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
regulation of transcription from RNA polymerase II promoter
apoptotic process
response to stress
acute-phase response
signal transduction
embryo implantation
response to nutrient
blood circulation
positive regulation of cell proliferation
response to salt stress
negative regulation of calcium ion transport into cytosol
positive regulation of neuron projection development
erythrocyte differentiation
response to lipopolysaccharide
myeloid cell apoptotic process
negative regulation of myeloid cell apoptotic process
response to vitamin A
response to testosterone
erythropoietin-mediated signaling pathway
positive regulation of activated T cell proliferation
hemoglobin biosynthetic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
erythrocyte maturation
response to estrogen
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of Ras protein signal transduction
response to axon injury
response to electrical stimulus
response to hyperoxia
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
cellular hyperosmotic response
response to dexamethasone
receptor signaling pathway via STAT
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
negative regulation of erythrocyte apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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