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Proteintech
TAB2 Polyclonal Antibody
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Product Details
14410-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TAB2 Fusion Protein Ag5742 (344-693 aa encoded by BC035910)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SGPRTSSTS SSVNSQTLNR NQPTVYIAAS PPNTDELMSR SQPKVYISAN AATGDEQVMR NQPTLFISTN SGASAASRNM SGQVSMGPAF IHHHPPKSRA IGNNSATSPR VVVTQPNTKY TFKITVSPNK PPAVSPGVVS PTFELTNLLN HPDHYVETEN IQHLTDPTLA HVDRISETRK LSMGSDDAAY TQALLVHQKA RMERLQRELE IQKKKLDKLK SEVNEMENNL TRRRLKRSNS ISQIPSLEEM QQLRSCNRQL QIDIDCLTKE IDLFQARGPH FNPSAIHNFY DNIGFVGPVP PKPKDQRSII KTPKTQDTED DEGAQWNCTA CTFLNHPALI RCEQCEMPRH F (344-693 aa encoded by BC035910)
Target Information
TAB2 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ21885; MAP3K7IP2; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; OTTHUMP00000017388; TAB-2; TAB2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2; unnamed protein product
Gene Aliases: 1110030N06Rik; A530078N03Rik; CHTD2; KIAA0733; MAP3K7IP2; mKIAA0733; TAB-2; TAB2
UniProt ID: (Human) Q9NYJ8, (Mouse) Q99K90, (Rat) Q5U303
Entrez Gene ID: (Human) 23118, (Mouse) 68652, (Rat) 308267
heart development
positive regulation of protein kinase activity
inflammatory response
I-kappaB kinase/NF-kappaB signaling
response to bacterium
negative regulation of autophagy
response to lipopolysaccharide
NIK/NF-kappaB signaling
p38MAPK cascade
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
protein K63-linked ubiquitination
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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