PA3-301 detects neurokinin-1 receptor in human samples.
PA3-301 has been successfully used in Western blot and immunohistochemistry (paraffin) procedures.
The PA3-301 immunogen is a synthetic peptide corresponding to residues S(387) S R S D S K T M T E S F S F S S N V L S(407) of human NK1 receptor protein.
NK1 receptors are frequently expressed in glioblastomas and breast and pancreatic carcinomas. Immunoreactive NK1 receptors are clearly confined to the plasma membrane and uniformly present on nearly all tumor cells. Development of this antibody allows efficient localization of NK1, and will facilitate identification of tumors with a sufficient receptor over-expression for diagnostic or therapeutic intervention.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NK-1 receptor; NK-1R; NK1R; NKIR; SPR; Substance-P receptor; TAC1R; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1
UniProt ID: (Human) P25103
Entrez Gene ID: (Human) 6869