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Invitrogen
TADA2L Polyclonal Antibody
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Product Details
PA5-104485
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TADA2A(Accession O75478), corresponding to amino acid residues R218-K268.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ADA2L.
Target Information
TADA2L (transcriptional adapter 2-like), also known as TADA2A (transcriptional adapter 2-alpha) or ADA2-like protein, is a 443 amino acid nuclear protein that exists as 2 alternatively spliced isoforms. While most abundantly expressed in testis, TADA2L is present in all tissues. TADA2L contains one SANT domain and one SWIRM domain, and interacts with GCN5 and GR (NR3C1). Its ability to bind double-stranded DNA allows TADA2L to play a role in chromatin remodeling. Although it makes up part of the PCAF complex, TADA2L is also a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. The gene that encodes TADA2L contains 71,408 bases and maps to human chromosome 17q12. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to osteogenesis imperfecta, Pendred syndrome, lissencephaly, citrullinemia and Shwachman-Diamond syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADA2-like protein; Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; transcriptional adaptor 2 alpha; unnamed protein product
Gene Aliases: ADA2; ADA2A; AV319371; D030022J10Rik; hADA2; KL04P; TADA2A; TADA2L
UniProt ID: (Human) O75478, (Rat) Q6AYE3, (Mouse) Q8CHV6
Entrez Gene ID: (Human) 6871, (Rat) 360581, (Mouse) 217031
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of embryonic development
regulation of cell division
regulation of cell cycle
regulation of protein phosphorylation
transcription, DNA-templated
mitotic nuclear division
biological_process
regulation of histone deacetylation
regulation of protein stability
histone H3 acetylation
regulation of tubulin deacetylation
histone acetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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