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Invitrogen
TADA2L Polyclonal Antibody
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FIGURE: 1 / 1
TADA2L Antibody (PA5-97063) in WB
Western blot analysis of TADA2L in extracts of various cell lines. Samples were incubated with TADA2L Polyclonal antibody (Product # PA5-97063) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 10s.
Product Details
PA5-97063
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-443 of human TADA2A (NP_0011595772)
Conjugate
Form
Liquid
Concentration
1.32 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MDRLGSFSND PSDKPPCRGC SSYLMEPYIK CAECGPPPFF LCLQCFTRGF EYKKHQSDHT YEIMTSDFPV LDPSWTAQEE MALLEAVMDC GFGNWQDVAN QMCTKTKEEC EKHYMKHFIN NPLFASTLLN LKQAEEAKTA DTAIPFHSTD DPPRPTFDSL LSRDMAGYMP ARADFIEEFD NYAEWDLRDI DFVEDDSDIL HALKMAVVDI YHSRLKERQR RKKIIRDHGL INLRKFQLME RRYPKEVQDL YETMRRFARI VGPVEHDKFI ESHALEFELR REIKRLQEYR TAGITNFCSA RTYDHLKKTR EEERLKRTML SEVLQYIQDS SACQQWLRRQ ADIDSGLSPS IPMASNSGRR SAPPLNLTGL PGTEKLNEKE KELCQMVRLV PGAYLEYKSA LLNECNKQGG LRLAQARALI KIDVNKTRKI YDFLIREGYI TKG; Positive Samples: BT-474, Mouse brain, Mouse skeletal muscle, Rat brain; Cellular Location: Chromosome, Nucleus
Target Information
TADA2L (transcriptional adapter 2-like), also known as TADA2A (transcriptional adapter 2-alpha) or ADA2-like protein, is a 443 amino acid nuclear protein that exists as 2 alternatively spliced isoforms. While most abundantly expressed in testis, TADA2L is present in all tissues. TADA2L contains one SANT domain and one SWIRM domain, and interacts with GCN5 and GR (NR3C1). Its ability to bind double-stranded DNA allows TADA2L to play a role in chromatin remodeling. Although it makes up part of the PCAF complex, TADA2L is also a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. The gene that encodes TADA2L contains 71,408 bases and maps to human chromosome 17q12. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to osteogenesis imperfecta, Pendred syndrome, lissencephaly, citrullinemia and Shwachman-Diamond syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADA2-like protein; Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; transcriptional adaptor 2 alpha
Gene Aliases: ADA2; ADA2A; AV319371; D030022J10Rik; hADA2; KL04P; TADA2A; TADA2L
UniProt ID: (Human) O75478, (Rat) Q6AYE3, (Mouse) Q8CHV6
Entrez Gene ID: (Human) 6871, (Rat) 360581, (Mouse) 217031
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription cofactor activity
transcription coactivator activity
histone acetyltransferase activity
protein binding
molecular_function
zinc ion binding
DNA-binding transcription factor
gene-specific transcriptional regulator
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of histone acetylation
histone H3 acetylation
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
mitotic nuclear division
biological_process
regulation of histone deacetylation
regulation of protein stability
regulation of tubulin deacetylation
histone acetylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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