|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 251 and 432 of Human TADA3L|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27591 targets TADA3L in WB applications and shows reactivity with Human samples.
The PA5-27591 immunogen is recombinant fragment corresponding to a region within amino acids 251 and 432 of Human TADA3L.
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADA3; ADA3 homolog; ADA3-like protein; alteration/deficiency in activation 3; hADA3; NGG1; STAF54; TADA3L; Transcriptional adapter 3; Transcriptional adapter 3-like
Gene Aliases: ADA3; hADA3; NGG1; STAF54; TADA3; TADA3L
UniProt ID: (Human) O75528
Entrez Gene ID: (Human) 10474
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