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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 70-320 of human TAF1C |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
1.13 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2806668 |
Immunogen sequence: PPLIDPWDPG LTARDLLFRG GYRYRKRPRV VLDVTEQISR FLLDHGDVAF APLGKLMLEN FKLEGAGSRT KKKTVVSVKK LLQDLGGHQP WGCPWAYLSN RQRRFSILGG PILGTSVASH LAELLHEELV LRWEQLLLDE ACTGGALAWV PGRTPQFGQL VYPAGGAQDR LHFQEVVLTP GDNPQFLGKP GRIQLQGPVR QVVTCTVQGE TLLAVRSDYH CAVWKFGKQW QPTLLQAMQV EKGATGISLS P; Positive Samples: 293T, MCF7, Mouse thymus; Cellular Location: Nucleus
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. TAF1C is the largest SL1-specific TAF. Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RNA polymerase I-specific TBP-associated factor 110 kDa; RNA polymerase I-specific TBP-associated factor 95 kDa; SL1, 110kD subunit; TAFI110; TAFI95; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C; transcription factor TAFI95; TATA box binding protein associated factor 1C; TATA box-binding protein-associated factor 1C; TATA box-binding protein-associated factor RNA polymerase I subunit C; TATA box-binding protein-associated factor, RNA polymerase I, subunit C; TATA-box binding protein associated factor, RNA polymerase I, C; TBP-associated factor 1C; TBP-associated factor RNA polymerase I 95 kDa; transcription factor SL1; transcription factor TAFI95; Transcription initiation factor SL1/TIF-IB subunit C
Gene Aliases: MGC:39976; mTAFI95; SL1; TAF1C; TAFI110; TAFI95
UniProt ID: (Human) Q15572, (Mouse) Q6PDZ2, (Rat) Q6P773
Entrez Gene ID: (Human) 9013, (Mouse) 21341, (Rat) 361420
Molecular Function:
DNA-directed RNA polymerase
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