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EBS-T-059 recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG72) with properties of a mucin and usually expressed by adenocarcinomas, but not by mesotheliomas and thus helps in the differential diagnosis of malignancies of the lung. The combined use of anti-TAG-72 and anti-GCDFP-15 is valuable in the diagnosis of apocrine carcinoma. TAG72 is further used as serum marker for gastric cancer.
Tumor-associated glycoprotein (TAG-72) is an oncofetal antigen with properties of a mucin. About 60% of carcinoma patients express TAG-72 in their sera.
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