PA5-29767 targets Transgelin in IF, IHC (P), and WB applications and shows reactivity with Human, Bovine, mouse, and Rat samples.
The PA5-29767 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 188 of Human Transgelin.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.
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Protein Aliases: 22 kDa actin-binding protein; 25 kDa F-actin-binding protein; Actin-associated protein p27; Protein WS3-10; SM22; SM22-alpha; Sm22alpha; SMCC; smooth muscle 22 protein; Smooth muscle protein 22-alpha; TAGLN1; Transgelin; transgelin variant 2; WS3-10
Gene Aliases: BOS_14359; SM22; Sm22a; SMCC; TAGLN; TAGLN1; WS3-10; Ws310