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Invitrogen

TAL1 Polyclonal Antibody

View all (27) TAL1 antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
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635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
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Product Details

Tested Applications
Dilution
Immunohistochemistry (Paraffin) (IHC (P))
4-8 µg/mL
Western Blot (WB)
0.6 µg/mL
Product Specifications
Species Reactivity
Bovine, Dog, Horse, Guinea pig, Human, Mouse, Rabbit, Rat
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human TAL1
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2609317

Product Specific Information

Peptide sequence: QDVLSPNSSC GSSLDGAASP DSYTEEPAPK HTARSLHPAM LPAADGAGPR

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 92%

Target Information

TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: bHLHa17; Class A basic helix-loop-helix protein 17; HGNC:11556; SCL; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell acute lymphocytic leukemia protein 1 homolog; T-cell leukemia/lymphoma protein 5; TAL-1; tal-1 product; TCL5

Gene Aliases: BHLHA17; BOS_3719; SCL; SCL/tal-1; Tal-1; TAL1; TCL5

UniProt ID: (Human) P17542, (Mouse) P22091

Entrez Gene ID: (Dog) 610331, (Human) 6886, (Bovine) 518657, (Rat) 313507, (Guinea pig) 100714614, (Mouse) 21349

Molecular Function: basic helix-loop-helix transcription factor nucleic acid binding transcription factor

Function(s)
negative regulation of transcription from RNA polymerase II promoter angiogenesis transcription, DNA-templated regulation of transcription from RNA polymerase II promoter locomotory behavior spinal cord association neuron differentiation hemopoiesis erythrocyte differentiation megakaryocyte differentiation platelet formation basophil differentiation positive regulation of protein complex assembly embryonic hemopoiesis megakaryocyte development regulation of cell proliferation erythrocyte maturation cell fate commitment positive regulation of erythrocyte differentiation positive regulation of chromatin assembly or disassembly positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of cell division astrocyte fate commitment definitive hemopoiesis hemangioblast cell differentiation hematopoietic stem cell differentiation regulation of mast cell differentiation regulation of stem cell population maintenance transcription from RNA polymerase II promoter biological_process myeloid cell differentiation neuron differentiation regulation of myeloid cell differentiation generation of neurons regulation of transcription, DNA-templated multicellular organism development cell differentiation
Process(es)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding enzyme binding histone deacetylase binding transcription regulatory region DNA binding protein heterodimerization activity E-box binding transcription regulatory region sequence-specific DNA binding molecular_function DNA binding protein dimerization activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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