Peptide sequence: QDVLSPNSSC GSSLDGAASP DSYTEEPAPK HTARSLHPAM LPAADGAGPR
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 92%
TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.
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Protein Aliases: bHLHa17; Class A basic helix-loop-helix protein 17; HGNC:11556; SCL; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell acute lymphocytic leukemia protein 1 homolog; T-cell leukemia/lymphoma protein 5; TAL-1; tal-1 product; TCL5
Gene Aliases: BHLHA17; BOS_3719; SCL; SCL/tal-1; Tal-1; TAL1; TCL5