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Invitrogen
TALK-1 Polyclonal Antibody
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Product Details
PA5-144235
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Potassium channel subfamily K member 16 protein (259-309AA)
Conjugate
Form
Liquid
Concentration
3.5 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The KCNK16 gene encodes the TALK-1 channel, an abundant K+ channel transcript found in mouse and in human Beta-cells. There are four human TALK-1 transcript variants, including two that form functional K+ channels (TALK-1a (transcript variant 2) and TALK1-b (transcript variant 3). The TALK-1 structure includes 4 transmembrane domains, 2 extracellular loops, and intracellular N- and C-termini. The C-terminal tail of TALK-1 is a critical component that influences the magnitude of TALK-1 channel activation, while the N-terminus is important for protein interaction. TALK-1, two-pore domain K+ (K2p 16.1) channel is responsible for modulating glucose stimulated insulin secretion that relies on Beta-cell CA2+ influx. The channel produces outwardly rectifying, non-inactivating K+ currents, which are enhanced by elevations in extracellular pH. TALK-1 is thus pH-sensitive, with increased activity under alkaline conditions. In addition, it can be activated by singlet oxygen and nitric oxide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2P domain potassium channel Talk-1; pancreatic potassium channel Talk-1; Potassium channel subfamily K member 16; potassium channel, subfamily K, member 16; potassium channel, two pore domain subfamily K, member 16; TALK-1; TWIK-related alkaline pH-activated K(+) channel 1; two-pore-domain potassium channel subunit
Gene Aliases: K2p16.1; KCNK16; TALK-1; TALK1
UniProt ID: (Human) Q96T55
Entrez Gene ID: (Human) 83795
ion transport
potassium ion transport
endoplasmic reticulum calcium ion homeostasis
ion transmembrane transport
regulation of membrane potential
regulation of release of sequestered calcium ion into cytosol
regulation of insulin secretion involved in cellular response to glucose stimulus
potassium ion transmembrane transport
membrane repolarization during action potential
regulation of action potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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