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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 3 publications 3 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | View 3 publications 3 publications |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
TAOK1 Fusion Protein Ag22461 (889-1001 aa encoded by BC133039) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.48 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: NMVLSNLSP EAFSHSYPGA SGWSHNPTGG PGPHWGHPMG GPPQAWGHPM QGGPQPWGHP SGPMQGVPRG SSMGVRNSPQ ALRRTASGGR TEQGMSRSTS VTSQISNGSH MSYT (889-1001 aa encoded by BC133039)
TAOK1 is a serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascase, DNA damage response, and regulations of cytoskeleton stability. It phosphorylates MAP2K3, MAP2K6, and MARK2. TAOK1 acts as an activator of the p38/MAPK cascade by mediating phosphorylation and subsequent activation of the upsteam MAP2K3 and MAP2K6 kinases. It is involved in G-protein couples receptor signaling to p38/MAPK14. In response to DNA damage, TAOK1, is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade by phosphorylaton of MAP2K3 and MAP2K6. In addition, it acts as a regulator of cytoskeleton stability and a regulator of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ14314; h hTAOK1; H KIAA1361; hKFC-B; Kinase from chicken homolog B; MARK Kinase; MARKK; microtubule affinity regulating kinase kinase; prostate-derived STE20-like kinase 2; Prostate-derived sterile 20-like kinase 2; PSK-2; serine/threonine protein kinase TAO1 homolog; Serine/threonine-protein kinase TAO1; STE20-like kinase PSK2; tao; TAOK1; Thousand and one amino acid protein 1; Thousand and one amino acid protein kinase 1
Gene Aliases: 2810468K05Rik; AU020252; D130018F14Rik; hKFC-B; hTAOK1; KFC-B; KIAA1361; MAP3K16; MARKK; mKIAA1361; PSK-2; PSK2; TAO1; TAOK1
UniProt ID: (Human) Q7L7X3, (Mouse) Q5F2E8
Entrez Gene ID: (Human) 57551, (Mouse) 216965
Molecular Function:
non-receptor serine/threonine protein kinase
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