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Product Details
PA1-24577
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
4.4 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic 16 amino acid peptide from internal region of human TAOK1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.1% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_561624 |
Product Specific Information
PA1-24577 detects Serine/threonine kinase TAO kinase 1 in Human samples.
Target Information
TAOK1 is a serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascase, DNA damage response, and regulations of cytoskeleton stability. It phosphorylates MAP2K3, MAP2K6, and MARK2. TAOK1 acts as an activator of the p38/MAPK cascade by mediating phosphorylation and subsequent activation of the upsteam MAP2K3 and MAP2K6 kinases. It is involved in G-protein couples receptor signaling to p38/MAPK14. In response to DNA damage, TAOK1, is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade by phosphorylaton of MAP2K3 and MAP2K6. In addition, it acts as a regulator of cytoskeleton stability and a regulator of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ14314; h hTAOK1; H KIAA1361; hKFC-B; Kinase from chicken homolog B; MARK Kinase; MARKK; microtubule affinity regulating kinase kinase; prostate-derived STE20-like kinase 2; Prostate-derived sterile 20-like kinase 2; PSK-2; serine/threonine protein kinase TAO1 homolog; Serine/threonine-protein kinase TAO1; STE20-like kinase PSK2; tao; TAOK1; thousand and one amino acid protein 1; Thousand and one amino acid protein kinase 1
Gene Aliases: hKFC-B; hTAOK1; KFC-B; KIAA1361; MAP3K16; MARKK; PSK-2; PSK2; TAO1; TAOK1
UniProt ID: (Human) Q7L7X3
Entrez Gene ID: (Human) 57551
Molecular Function:
non-receptor serine/threonine protein kinase
DNA repair
protein phosphorylation
cellular response to DNA damage stimulus
sister chromatid cohesion
signal transduction by protein phosphorylation
G2 DNA damage checkpoint
spindle checkpoint
positive regulation of stress-activated MAPK cascade
positive regulation of JNK cascade
regulation of cytoskeleton organization
execution phase of apoptosis
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