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|Tested species reactivity||Human , Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||synthetic peptide AKLVQRQMLGLQPA, corresponding to amino acids 735-748 of Human TAP1.|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay dependent|
|Western Blot (WB)||1:4000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-28108 detects TAP1 from human, rat samples.
PA1-28108 has been successfully used in immunocytochemistry, immunoprecipitation, Western blot applications.
The PA1-28108 immunogen is: Synthetic peptide: AKLVQRQMLGLQPA, corresponding to amino acids 735-748 of Human TAP1.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ABC transporter, MHC 1; ABC17; ABCB2; antigen peptide transporter 1; APT1; ATP-binding cassette sub-family B member 2; ATP-binding cassette, sub-family B (MDR/TAP), member 2; D6S114E; DAAP-57C1.5; FLJ26666; FLJ41500; peptide supply factor 1; peptide transporter involved in antigen processing 1; peptide transporter PSF1; peptide transporter TAP1; PSF1; really interesting new gene 4 protein; RING4; TAP1*0102N; TAP1N; transporter 1 ABC (ATP binding cassette); transporter 1 ATP-binding cassette sub-family B; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; transporter, ATP-binding cassette, major histocompatibility complex, 1
ABC17; ABCB2; APT1; Cim; D6S114E; PSF-1; PSF1; RING4; TAP1; TAP1*0102N; TAP1N; Tap2; Y3