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Invitrogen
TAP1 Polyclonal Antibody
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FIGURE: 1 / 1
TAP1 Antibody (PA5-110458) in WB
Western blot analysis of TAP1 in extracts of various cell lines. Samples were incubated with TAP1 Polyclonal antibody (Product # PA5-110458) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-110458
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 524-808 of human TAP1 (NP_0005843)
Conjugate
Form
Liquid
Concentration
0.76 mg/mL
Amount
76 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IYPRVQKAVG SSEKIFEYLD RTPRCPPSGL LTPLHLEGLV QFQDVSFAYP NRPDVLVLQG LTFTLRPGEV TALVGPNGSG KSTVAALLQN LYQPTGGQLL LDGKPLPQYE HRYLHRQVAA VGQEPQVFGR SLQENIAYGL TQKPTMEEIT AAAVKSGAHS FISGLPQGYD TEVDEAGSQL SGGQRQAVAL ARALIRKPCV LILDDATSAL DANSQLQVEQ LLYESPERYS RSVLLITQHL SLVEQADHIL FLEGGAIREG GTHQQLMEKK GCYWAMVQAP ADAPE
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter, MHC 1; ABC transporter, MHC, 1; ABP-278; ABP-280; ABP-280 homolog; Antigen peptide transporter 1; AOI; APT1; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 2; ATP-binding cassette transporter, major histocompatibility complex, 1; ATP-binding cassette, sub-family B (MDR/TAP), member 2; beta-filamin; DAAP-57C1.5; FH1; filamin homolog 1; filamin-3; filamin-B; FLJ26666; FLJ41500; FLN-B; FLN1L; Histocompatibility antigen modifier 1; LRS1; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF1; Peptide transporter TAP1; PSF-1; Really interesting new gene 4 protein; RING4; SCT; TABP; tap i; thyroid autoantigen; transporter 1 ATP-binding cassette sub-family B; transporter 1 ATP-binding cassette sub-family B (MDR/TAP) isoform TAP1_1; transporter 1 ATP-binding cassette sub-family B (MDR/TAP) isoform TAP1_2; transporter 1, ABC (ATP binding cassette); transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; transporter associated with antigen processing 1; transporter, ABC, MHC, 1; transporter, ATP-binding cassette, major histocompatibility complex, 1; Unknown; unnamed protein product; Y3
Gene Aliases: ABC17; ABCB2; APT1; D6S114E; Ham-1; Ham1; MHC1D1; MTP1; PSF-1; PSF1; RING4; TAP; Tap-1; TAP1; TAP1*0102N; TAP1N; Y3
UniProt ID: (Human) Q03518, (Mouse) P21958
Entrez Gene ID: (Human) 6890, (Mouse) 21354
nucleotide binding
protein binding
ATP binding
peptide antigen-transporting ATPase activity
peptide-transporting ATPase activity
ATPase activity
MHC class Ib protein binding
MHC protein binding
MHC class I protein binding
peptide antigen binding
protein homodimerization activity
ADP binding
metal ion binding
TAP1 binding
TAP2 binding
ABC-type transporter activity
peptide transmembrane transporter activity
peptide transporter activity
ATPase activity, coupled to transmembrane movement of substances
tapasin binding
protein heterodimerization activity
ATP-binding cassette (ABC) transporter
adaptive immune response
immune system process
peptide antigen assembly with MHC class I protein complex
defense response
protein transport
peptide transport
antigen processing and presentation of endogenous peptide antigen via MHC class I
cytosol to ER transport
transmembrane transport
transport
metabolic process
intracellular transport of viral protein in host cell
protection from natural killer cell mediated cytotoxicity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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