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Invitrogen
TAP1 Polyclonal Antibody
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FIGURE: 1 / 3
TAP1 Antibody (PA5-116006) in ICC/IF
Immunocytochemistry analysis of TAP1 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-116006) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Product Details
PA5-116006
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TAP1(Accession Q03518), corresponding to amino acid residues A19-P69.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TAP1.
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter, MHC 1; ABC transporter, MHC, 1; ABP-278; ABP-280; ABP-280 homolog; Antigen peptide transporter 1; AOI; APT1; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 2; ATP-binding cassette transporter, major histocompatibility complex, 1; ATP-binding cassette, sub-family B (MDR/TAP), member 2; beta-filamin; DAAP-57C1.5; FH1; filamin homolog 1; filamin-3; filamin-B; FLJ26666; FLJ41500; FLN-B; FLN1L; Histocompatibility antigen modifier 1; LRS1; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF1; Peptide transporter TAP1; PSF-1; Really interesting new gene 4 protein; RING4; SCT; TABP; tap i; thyroid autoantigen; transporter 1 ATP-binding cassette sub-family B; transporter 1 ATP-binding cassette sub-family B (MDR/TAP) isoform TAP1_1; transporter 1 ATP-binding cassette sub-family B (MDR/TAP) isoform TAP1_2; transporter 1, ABC (ATP binding cassette); transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; transporter associated with antigen processing 1; transporter, ABC, MHC, 1; transporter, ATP-binding cassette, major histocompatibility complex, 1; Unknown; unnamed protein product; Y3
Gene Aliases: ABC17; ABCB2; APT1; D6S114E; Ham-1; Ham1; MHC1D1; MTP1; PSF-1; PSF1; RING4; TAP; Tap-1; TAP1; TAP1*0102N; TAP1N; Y3
UniProt ID: (Human) Q03518, (Mouse) P21958
Entrez Gene ID: (Human) 6890, (Mouse) 21354
nucleotide binding
protein binding
ATP binding
peptide antigen-transporting ATPase activity
peptide-transporting ATPase activity
ATPase activity
MHC class Ib protein binding
MHC protein binding
MHC class I protein binding
peptide antigen binding
protein homodimerization activity
ADP binding
metal ion binding
TAP1 binding
TAP2 binding
ABC-type transporter activity
peptide transmembrane transporter activity
peptide transporter activity
ATPase activity, coupled to transmembrane movement of substances
tapasin binding
protein heterodimerization activity
ATP-binding cassette (ABC) transporter
adaptive immune response
immune system process
peptide antigen assembly with MHC class I protein complex
defense response
protein transport
peptide transport
antigen processing and presentation of endogenous peptide antigen via MHC class I
cytosol to ER transport
transmembrane transport
transport
metabolic process
intracellular transport of viral protein in host cell
protection from natural killer cell mediated cytotoxicity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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