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Invitrogen
TAT complex Monoclonal Antibody (C1)
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FIGURE: 1 / 1
TAT complex Antibody (MA5-51121) in WB
Western blot analysis of TAT complex in Human Serum. Samples were incubated with TAT complex monoclonal antibody (Product # MA5-51121) using a dilution of 0.2 µg/mL followed by HRP-Linked Caprine Anti-Mouse IgG secondary antibody at a dilution of 0.2 µg/mL.
Product Details
MA5-51121
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
C1
Immunogen
Recombinant Human TAT protein, Ile364-Glu622 + GGGGS*3 + His33-Lys464 (Accession #P00734 & P01008)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The Thrombin-antithrombin complex (TAT complex) is a protein complex formed by the binding of thrombin, a serine protease involved in blood clotting, and antithrombin, a serine protease inhibitor that regulates thrombin activity. This complex plays a crucial role in maintaining the balance between blood clotting and preventing excessive clotting, which can lead to thrombosis. The complex is formed when antithrombin binds to thrombin, inhibiting its activity and preventing the formation of blood clots.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antithrombin-III; antithrombin-III precursor; ATIII; Coagulation factor II; prepro-coagulation factor II; Prothrombin; prothrombin B-chain; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; Serpin C1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; TAT; thrombin factor II; thrombin precursor; unnamed protein product
Gene Aliases: AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; F2; PRO0309; PT; RPRGL2; SERPINC1; THPH1; THPH7
UniProt ID: (Human) P00734, (Human) P01008
Entrez Gene ID: (Human) 2147, (Human) 462
lipopolysaccharide binding
endopeptidase activity
serine-type endopeptidase activity
receptor binding
calcium ion binding
protein binding
growth factor activity
heparin binding
peptidase activity
serine-type peptidase activity
hydrolase activity
receptor agonist activity
thrombospondin receptor activity
protease binding
serine-type endopeptidase inhibitor activity
peptidase inhibitor activity
identical protein binding
blood coagulation
hemostasis
regulation of blood coagulation
proteolysis
acute-phase response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
negative regulation of platelet activation
platelet activation
positive regulation of blood coagulation
negative regulation of blood coagulation
positive regulation of cell growth
positive regulation of insulin secretion
positive regulation of collagen biosynthetic process
fibrinolysis
negative regulation of proteolysis
positive regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
regulation of body fluid levels
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
cytolysis by host of symbiont cells
positive regulation of protein kinase B signaling
negative regulation of fibrinolysis
antimicrobial humoral immune response mediated by antimicrobial peptide
thrombin receptor signaling pathway
neutrophil mediated killing of gram-negative bacterium
negative regulation of cytokine production involved in inflammatory response
positive regulation of protein localization to nucleus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
ligand-gated ion channel signaling pathway
positive regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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