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Invitrogen

TAT complex Monoclonal Antibody (C1)

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TAT complex Monoclonal Antibody (C1)

Product Details

MA5-51121

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

C1

Immunogen

Recombinant Human TAT protein, Ile364-Glu622 + GGGGS*3 + His33-Lys464 (Accession #P00734 & P01008)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3093505

Target Information

The Thrombin-antithrombin complex (TAT complex) is a protein complex formed by the binding of thrombin, a serine protease involved in blood clotting, and antithrombin, a serine protease inhibitor that regulates thrombin activity. This complex plays a crucial role in maintaining the balance between blood clotting and preventing excessive clotting, which can lead to thrombosis. The complex is formed when antithrombin binds to thrombin, inhibiting its activity and preventing the formation of blood clots.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Antithrombin-III; antithrombin-III precursor; ATIII; Coagulation factor II; prepro-coagulation factor II; Prothrombin; prothrombin B-chain; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; Serpin C1; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1; TAT; thrombin factor II; thrombin precursor; unnamed protein product

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Gene Aliases: AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; F2; PRO0309; PT; RPRGL2; SERPINC1; THPH1; THPH7

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UniProt ID: (Human) P00734, (Human) P01008

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Entrez Gene ID: (Human) 2147, (Human) 462

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Function(s)
lipopolysaccharide binding endopeptidase activity serine-type endopeptidase activity receptor binding calcium ion binding protein binding growth factor activity heparin binding peptidase activity serine-type peptidase activity hydrolase activity receptor agonist activity thrombospondin receptor activity protease binding serine-type endopeptidase inhibitor activity peptidase inhibitor activity identical protein binding
Process(es)
blood coagulation hemostasis regulation of blood coagulation proteolysis acute-phase response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cell proliferation regulation of cell shape response to wounding regulation of gene expression negative regulation of platelet activation platelet activation positive regulation of blood coagulation negative regulation of blood coagulation positive regulation of cell growth positive regulation of insulin secretion positive regulation of collagen biosynthetic process fibrinolysis negative regulation of proteolysis positive regulation of JAK-STAT cascade negative regulation of astrocyte differentiation regulation of body fluid levels positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration cytolysis by host of symbiont cells positive regulation of protein kinase B signaling negative regulation of fibrinolysis antimicrobial humoral immune response mediated by antimicrobial peptide thrombin receptor signaling pathway neutrophil mediated killing of gram-negative bacterium negative regulation of cytokine production involved in inflammatory response positive regulation of protein localization to nucleus positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway ligand-gated ion channel signaling pathway positive regulation of reactive oxygen species metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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