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Invitrogen
TAUT Polyclonal Antibody
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Product Details
PA5-37460
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 570-620 of human TAUT
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 70 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Taurine is an abundant organic osmolyte that possesses antioxidant and immunomodulatory properties and plays a role in cell volume homeostasis. Taurine is taken up into cells via the taurine transporter (TAUT). TAUT, which is sodium- and chloride-dependent, is a multi-pass membrane protein belonging to the sodium neurotransmitter symporter (SNF) family of proteins. TNF alpha upregulates TAUT expression, while phosphorylation on Serine 322 downregulates it. Overexpression of TAUT protects renal cells from cisplatin-induced nephrotoxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC10619; MGC131729; OTTHUMP00000208177; OTTHUMP00000208180; SC6A6; Sodium- and chloride-dependent taurine transporter; Solute carrier 6 ,member 6 (taurine transporter); solute carrier family 6 (neurotransmitter transporter, taurine), member 6; Solute carrier family 6 member 6; solute carrier family 6, member 6; Taurine Transporter; taurine/beta-alanine transporter; TauT; unnamed protein product
Gene Aliases: AA589629; C80501; HTRDC; SLC6A6; TAUT
UniProt ID: (Human) P31641, (Mouse) O35316, (Rat) P31643
Entrez Gene ID: (Human) 6533, (Mouse) 21366, (Rat) 29464
sodium:amino acid symporter activity
gamma-aminobutyric acid:sodium symporter activity
taurine transmembrane transporter activity
taurine:sodium symporter activity
amino acid transmembrane transporter activity
gamma-aminobutyric acid transmembrane transporter activity
symporter activity
alanine transmembrane transporter activity
beta-alanine transmembrane transporter activity
neurotransmitter:sodium symporter activity
taurine binding
primary active transporter
neurotransmitter transport
amino acid transport
taurine transport
alanine transport
sodium ion transmembrane transport
positive regulation of cell differentiation
modulation of synaptic transmission
gamma-aminobutyric acid import
amino acid import across plasma membrane
import across plasma membrane
transport across blood-brain barrier
beta-alanine transport
amino acid transmembrane transport
transport
organic acid transmembrane transport
organic acid transport
transmembrane transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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