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TBK1 Polyclonal Antibody, MaxPab™

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TBK1 Polyclonal Antibody, MaxPab™

Product Details

H00029110-D01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TBK1 (NP_037386.1, 1 a.a. approximately 729 a.a) full-length human protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG KPSGAISGVQ KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA ETSDILHRMV IHVFSLQQMT AHKIYIHSYN TATIFHELVY KQTKIISSNQ ELIYEGRRLV LEPGRLAQHF PKTTEENPIF VVSREPLNTI GLIYEKISLP KVHPRYDLDG DASMAKAITG VVCYACRIAS TLLLYQELMR KGIRWLIELI KDDYNETVHK KTEVVITLDF CIRNIEKTVK VYEKLMKINL EAAELGEISD IHTKLLRLSS SQGTIETSLQ DIDSRLSPGG SLADAWAHQE GTHPKDRNVE KLQVLLNCMT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH FTDECVKKYE AFLNKSEEWI RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY TNELQETLPQ KMFTASSGIK HTMTPIYPSS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGSLTMD GGLRNVDCL

Target Information

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; protein kinase; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; tbk; unnamed protein product

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Gene Aliases: AIARV; FTDALS4; IIAE8; NAK; T2K; TBK1

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UniProt ID: (Human) Q9UHD2

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Entrez Gene ID: (Human) 29110

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Function(s)
nucleotide binding nucleic acid binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity protein phosphatase binding identical protein binding phosphoprotein binding RNA polymerase II sequence-specific DNA binding transcription factor binding protein serine kinase activity
Process(es)
cytoplasmic translation activation of innate immune response immune system process cytoplasmic pattern recognition receptor signaling pathway protein phosphorylation protein import into nucleus inflammatory response I-kappaB kinase/NF-kappaB signaling mRNA transcription response to virus regulation of gene expression positive regulation of autophagy negative regulation of gene expression macroautophagy positive regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation regulation of metabolic process signal transduction involved in regulation of gene expression cellular response to nutrient levels positive regulation of TOR signaling regulation of type I interferon production negative regulation of type I interferon production positive regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production toll-like receptor 4 signaling pathway TORC1 signaling TORC2 signaling positive regulation of I-kappaB kinase/NF-kappaB signaling protein kinase B signaling dendritic cell proliferation innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation defense response to Gram-positive bacterium defense response to virus positive regulation of protein kinase B signaling type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway T follicular helper cell differentiation defense response to other organism antiviral innate immune response cGAS/STING signaling pathway positive regulation of cytokine production involved in inflammatory response negative regulation of TORC1 signaling positive regulation of TORC1 signaling positive regulation of xenophagy positive regulation of TORC2 signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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