TBRG1 acts as a growth inhibitor. It can activate TP53/p53, cause G1 arrest and collaborate with CDKN2A to restrict proliferation, but it does not require either protein to inhibit DNA synthesis. TBRG1 redistributes CDKN2A into the nucleoplasm, and is involved in maintaining chromosomal stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Nuclear interactor of ARF and Mdm2; Transforming growth factor beta regulator 1
Gene Aliases: NIAM; TB-5; TBRG1
UniProt ID: (Human) Q3YBR2
Entrez Gene ID: (Human) 84897