Immunogen sequence: YQWVKFDVCKP GDGQLPEGLP ENDAAMSFEA FQRQIFDEDQ NDPLLPGSLD LPELQPAAFV SSYQPMYLTH EPLVDTHLQH LKSPSQGSPI
Highest antigen sequence identity to the following orthologs - mouse 77%, rat 77%.
TBRG1 acts as a growth inhibitor. It can activate TP53/p53, cause G1 arrest and collaborate with CDKN2A to restrict proliferation, but it does not require either protein to inhibit DNA synthesis. TBRG1 redistributes CDKN2A into the nucleoplasm, and is involved in maintaining chromosomal stability.
Protein Aliases: Nuclear interactor of ARF and Mdm2; Transforming growth factor beta regulator 1
Gene Aliases: NIAM; TB-5; TBRG1
UniProt ID: (Human) Q3YBR2
Entrez Gene ID: (Human) 84897