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Invitrogen
TBX1 Polyclonal Antibody
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FIGURE: 1 / 6
TBX1 Antibody (34-9800) in IHC (P)
Immunohistochemistry analysis of T-BOX 1 showing staining in the cytoplasm and weak staining in the nucleus of paraffin-embedded mouse skeletal muscle tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2... View More
Product Details
34-9800
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
C. elegans,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the internal region of the mouse T-box 1 (Tbx1) protein.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: T-box protein 1; T-box transcription factor TBX1; Testis-specific T-box protein
Gene Aliases: Tbx1
UniProt ID: (Mouse) P70323
Entrez Gene ID: (Mouse) 21380
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
blood vessel development
patterning of blood vessels
cell fate specification
neural crest cell migration
positive regulation of protein phosphorylation
lymph vessel development
blood vessel remodeling
positive regulation of mesenchymal cell proliferation
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
multicellular organism development
determination of left/right symmetry
pattern specification process
mesoderm development
heart development
muscle organ development
sensory perception of sound
cell proliferation
positive regulation of cell proliferation
anterior/posterior pattern specification
vagus nerve morphogenesis
epithelial cell differentiation
thyroid gland development
social behavior
aorta morphogenesis
ear morphogenesis
inner ear morphogenesis
outer ear morphogenesis
middle ear morphogenesis
odontogenesis of dentin-containing tooth
muscle cell fate commitment
positive regulation of MAPK cascade
tongue morphogenesis
cellular response to fibroblast growth factor stimulus
negative regulation of cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
blood vessel morphogenesis
thymus development
muscle organ morphogenesis
embryonic cranial skeleton morphogenesis
embryonic viscerocranium morphogenesis
semicircular canal morphogenesis
artery morphogenesis
positive regulation of epithelial cell proliferation
parathyroid gland development
soft palate development
pharyngeal system development
face morphogenesis
muscle tissue morphogenesis
coronary artery morphogenesis
enamel mineralization
otic vesicle morphogenesis
positive regulation of secondary heart field cardioblast proliferation
cochlea morphogenesis
mesenchymal cell apoptotic process
regulation of organ morphogenesis
positive regulation of tongue muscle cell differentiation
negative regulation of mesenchymal cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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