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Proteintech
TBX18 Polyclonal Antibody
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Product Details
23237-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TBX18 Fusion Protein Ag19258 (350-532 aa encoded by BC157841)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically reacts with the 65 kDa TBX18 protein.
Immunogen sequence: PSLRTLTFE DIPGIPKQGN ASSSTLLQGT GNGVPATHPH LLSGSSCSSP AFHLGPNTSQ LCSLAPADYS ACARSGLTLN RYSTSLAETY NRLTNQAGET FAPPRTPSYV GVSSSTSVNM SMGGTDGDTF SCPQTSLSMQ ISGMSPQLQY IMPSPSSNAF ATNQTHQGSY NTFRLHSPCA LYGY (350-532 aa encoded by B C157841)
Target Information
The T-box (Tbx) motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation. The Tbx gene family are largely conserved throughout metazoan evolution, and these genes code for putative transcription factors that share a uniquely defining DNA-binding domain. Tbx genes are a family of developmental regulators with more than 20 members recently identified in invertebrates and vertebrates. Mutations in Tbx genes are associated with the onset of several human diseases. Our understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/Brachyury, which is a transcription activator. The Tbx genes constitute a family of transcriptional regulatory genes that are implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: T-box 18; T-box protein 14; T-box protein 15; T-box protein 18; T-box transcription factor TBX18; TBX14; TBX15
Gene Aliases: 2810012F10Rik; 2810404D13Rik; CAKUT2; PUJO; TBX18
UniProt ID: (Human) O95935, (Mouse) Q9EPZ6
Entrez Gene ID: (Human) 9096, (Rat) 315870, (Mouse) 76365
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific double-stranded DNA binding
transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II transcription corepressor activity
molecular_function
protein heterodimerization activity
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell fate specification
somitogenesis
sinoatrial node development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
morphogenesis of embryonic epithelium
neural plate anterior/posterior regionalization
positive regulation of transcription, DNA-templated
smooth muscle cell differentiation
sinoatrial node cell fate commitment
sinoatrial node cell development
ureter development
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
regulation of SA node cell action potential
positive regulation of mesenchymal cell proliferation
transcription, DNA-templated
transcription from RNA polymerase II promoter
sensory perception of sound
biological_process
anterior/posterior axis specification
positive regulation of cell-cell adhesion
cell differentiation
anatomical structure formation involved in morphogenesis
positive regulation of epithelial cell proliferation
negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
positive regulation of mesenchymal cell proliferation involved in ureter development
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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