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Product Details
23237-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
TBX18 Fusion Protein Ag19258 (350-532 aa encoded by BC157841) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.35 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
This antibody specifically reacts with the 65 kDa TBX18 protein.
Immunogen sequence: PSLRTLTFE DIPGIPKQGN ASSSTLLQGT GNGVPATHPH LLSGSSCSSP AFHLGPNTSQ LCSLAPADYS ACARSGLTLN RYSTSLAETY NRLTNQAGET FAPPRTPSYV GVSSSTSVNM SMGGTDGDTF SCPQTSLSMQ ISGMSPQLQY IMPSPSSNAF ATNQTHQGSY NTFRLHSPCA LYGY (350-532 aa encoded by B C157841)
Target Information
The T-box (Tbx) motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation. The Tbx gene family are largely conserved throughout metazoan evolution, and these genes code for putative transcription factors that share a uniquely defining DNA-binding domain. Tbx genes are a family of developmental regulators with more than 20 members recently identified in invertebrates and vertebrates. Mutations in Tbx genes are associated with the onset of several human diseases. Our understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/Brachyury, which is a transcription activator. The Tbx genes constitute a family of transcriptional regulatory genes that are implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T-box protein 18; T-box transcription factor TBX18; TBX14; TBX15
Gene Aliases: 2810012F10Rik; 2810404D13Rik; CAKUT2; TBX18
UniProt ID: (Human) O95935, (Mouse) Q9EPZ6
Entrez Gene ID: (Human) 9096, (Rat) 315870, (Mouse) 76365
Molecular Function:
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation
renal system development
somitogenesis
positive regulation of mesenchymal cell proliferation
sinoatrial node development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
sensory perception of sound
biological_process
anterior/posterior axis specification
morphogenesis of embryonic epithelium
positive regulation of cell-cell adhesion
cell differentiation
anatomical structure formation involved in morphogenesis
positive regulation of epithelial cell proliferation
smooth muscle cell differentiation
ureter development
cochlea morphogenesis
positive regulation of mesenchymal cell proliferation involved in ureter development
multicellular organism development
transcription regulatory region sequence-specific DNA binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
protein heterodimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
molecular_function
DNA binding
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