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Proteintech
TBX2 Polyclonal Antibody
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Product Details
22346-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TBX2 Fusion Protein Ag17860 (289-563 aa encoded by BC052566)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LTLPSLRLY EEHCKPERDG AESDASSCDP PPAREPPTSP GAAPSPLRLH RARAEEKSCA ADSDPEPERL SEERAGAPLG RSPAPDSASP TRLTEPERAR ERRSPERGKE PAESGGDGPF GLRSLEKERA EARRKDEGRK EAAEGKEQGL APLVVQTDSA SPLGAGHLPG LAFSSHLHGQ QFFGPLGAGQ PLFLHPGQFT MGPGAFSAMG MGHLLASVAG GGNGGGGGPG TAAGLDAGGL GPAASAASTA APFPFHLSQH MLASQGIPMP TFGGLF (289-563 aa encoded by BC052566)
Target Information
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ10169; T-box 2; T-box gene; T-box protein 2; T-box transcription factor TBX2
Gene Aliases: TBX2; VETD
UniProt ID: (Human) Q13207, (Mouse) Q60707
Entrez Gene ID: (Human) 6909, (Mouse) 21385
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
histone deacetylase binding
sequence-specific DNA binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell fate specification
heart looping
heart morphogenesis
outflow tract septum morphogenesis
outflow tract morphogenesis
endocardial cushion morphogenesis
endocardial cushion formation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
Notch signaling pathway
muscle cell fate determination
regulation of heart contraction
fibroblast growth factor receptor signaling pathway
neurogenesis
response to retinoic acid
embryonic heart tube development
aorta morphogenesis
atrioventricular canal development
embryonic digit morphogenesis
pigment metabolic process involved in pigmentation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic camera-type eye morphogenesis
cardiac muscle tissue development
smooth muscle cell differentiation
palate development
pharyngeal system development
positive regulation of cardiac muscle cell proliferation
cardiac muscle cell myoblast differentiation
epithelial tube branching involved in lung morphogenesis
developmental growth involved in morphogenesis
mammary placode formation
mesenchymal cell proliferation involved in lung development
cellular response to dexamethasone stimulus
ureteric peristalsis
cochlea morphogenesis
cellular senescence
melanocyte proliferation
negative regulation of heart looping
negative regulation of cardiac chamber formation
positive regulation of cell cycle G1/S phase transition
cardiac jelly development
atrioventricular canal morphogenesis
negative regulation of cellular senescence
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
cell aging
positive regulation of cell proliferation
pharynx development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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