Peptide sequence: AEIAQAEEQA RKRQEEREKE AAEQAERSQS SIVPEEEQAA NKGEEKKDDE
Sequence homology: Cow: 92%; Dog: 85%; Guinea Pig: 85%; Horse: 92%; Human: 100%; Mouse: 77%; Pig: 92%; Rabbit: 92%; Rat: 85%
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
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Protein Aliases: FLJ10169; T-box 2; T-box 2 protein; T-box 2 transcription factor; T-box protein 2; T-box transcription factor TBX2
Gene Aliases: BOS_18403; TBX2