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Invitrogen
TBX3 Polyclonal Antibody
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Product Details
PA5-141012
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within mouse TBX3 aa 401-445.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bladder cancer related protein XHL; T-box 3; T-box 3 (ulnar mammary syndrome); T-box gene; T-box protein 3; T-box transcription factor TBX3; unnamed protein product
Gene Aliases: D5Ertd189e; TBX3; TBX3-ISO; UMS; XHL
UniProt ID: (Human) O15119, (Mouse) P70324, (Rat) Q7TST9
Entrez Gene ID: (Human) 6926, (Mouse) 21386, (Rat) 353305
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
molecular_function
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
blood vessel development
in utero embryonic development
cell fate specification
heart looping
heart morphogenesis
outflow tract morphogenesis
atrioventricular bundle cell differentiation
endocardial cushion formation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
organ morphogenesis
specification of organ position
stem cell population maintenance
limbic system development
male genitalia development
female genitalia development
negative regulation of epithelial cell differentiation
mammary gland development
regulation of protein stability
luteinizing hormone secretion
embryonic heart tube development
limb morphogenesis
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
forelimb morphogenesis
atrioventricular canal development
regulation of cell proliferation
inner ear morphogenesis
embryonic digit morphogenesis
negative regulation of apoptotic process
negative regulation of myoblast differentiation
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
follicle-stimulating hormone secretion
mesoderm morphogenesis
semicircular canal morphogenesis
smooth muscle cell differentiation
cardiac muscle cell differentiation
palate development
cardiac epithelial to mesenchymal transition
ventricular septum morphogenesis
branching involved in mammary gland duct morphogenesis
mammary placode formation
cardiac muscle cell fate commitment
sinoatrial node cell development
hepatoblast differentiation
regulation of protein complex stability
stem cell proliferation
ureteric peristalsis
cellular senescence
cardiac jelly development
atrioventricular canal morphogenesis
negative regulation of cell proliferation involved in heart morphogenesis
positive regulation of stem cell proliferation
negative regulation of stem cell differentiation
transcription from RNA polymerase II promoter
multicellular organism development
cell aging
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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