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Abnova
TBX5 Monoclonal Antibody (1G10)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
H00006910-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1G10
Immunogen
TBX5 (AAH27942, 402 a.a. approximately 518 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: PSMPSYSSCT VTTVQPMDRL PYQHFSAHFT SGPLVPRLAG MANHGSPQLG EGMFQHQTSV AHQPVVRQCG PQTGLQSPGT LQPPEFLYSH GVPRTLSPHQ YHSVHGVGMV PEWSDNS
Target Information
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T-box 5; T-box protein 5; TBX5; unnamed protein product
Gene Aliases: HOS
UniProt ID: (Human) Q99593
Entrez Gene ID: (Human) 6910
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
cell fate specification
sinoatrial node development
bundle of His development
atrioventricular bundle cell differentiation
cardiac left ventricle formation
ventricular septum development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell-cell signaling
pattern specification process
heart development
negative regulation of cell proliferation
negative regulation of epithelial to mesenchymal transition
embryonic limb morphogenesis
negative regulation of cell migration
embryonic forelimb morphogenesis
forelimb morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cardioblast differentiation
cardiac muscle cell differentiation
pericardium development
negative regulation of cardiac muscle cell proliferation
regulation of atrial cardiac muscle cell membrane depolarization
atrioventricular node cell development
atrioventricular node cell fate commitment
cell migration involved in coronary vasculogenesis
bundle of His cell to Purkinje myocyte communication by electrical coupling
positive regulation of cell communication by electrical coupling involved in cardiac conduction
positive regulation of gap junction assembly
positive regulation of cardiac conduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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