Positive Control: mouse muscle
Predicted Reactivity: Rat (91%), Dog (90%), Pig (92%), Rhesus Monkey (98%), Bovine (94%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 19 kDa sarcomeric protein; CMD1N; LGMD2G; limb girdle muscular dystrophy 2G (autosomal recessive); T-cap; TCAP; TELE; Telethonin; teneurin C-terminal associated peptide; Titin cap protein; titin-cap (telethonin)
Gene Aliases: AI503981; AJ223855; CMD1N; CMH25; LGMD2G; T-cap; TCAP; TELE; telethonin
Molecular Function: cytoskeletal protein