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Immunogen sequence: AESPKTPSSP LTPTFASSMC LLAPCYLTGD SVRDKCVEML SAALKADDDY KDYGVNCDKM ASEIEDH
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: rhabdomyosarcoma antigen MU-RMS-40.22; transcription elongation factor A (SII), 3; Transcription elongation factor A protein 3; Transcription elongation factor S-II protein 3; Transcription elongation factor TFIIS.h
Gene Aliases: TCEA3; TFIIS; TFIIS.H; TFIISH
UniProt ID: (Human) O75764
Entrez Gene ID: (Human) 6920
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