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Product Details
PA5-68595
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.2-1.0 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
synthetic peptide directed towards the N terminal region of human TCF21 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 2% sucrose |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2688362 |
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Target Information
The basic helix-loop-helix transcription factor TCF21/Pod1 (also called capsulin or epicardin) is involved in kidney, lung and spleen organogenesis. It is also essential for normal development of the testes and ovaries. TCF21/Pod1 is involved in the transcriptional repression of steroidogenic factor 1 (Sf1/Nr5a1/Ad4BP), an orphan nuclear receptor that regulates the expression of multiple genes (including Scc) that mediate sexual differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa23; Capsulin; Class A basic helix-loop-helix protein 23; Epicardin; Pod-1; Podocyte-expressed 1; TCF-21; Transcription factor 21
Gene Aliases: BHLHA23; POD1; TCF21
UniProt ID: (Human) O43680
Entrez Gene ID: (Human) 6943
Molecular Function:
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
branching involved in ureteric bud morphogenesis
morphogenesis of a branching structure
kidney development
vasculature development
transcription from RNA polymerase II promoter
sex determination
branchiomeric skeletal muscle development
epithelial cell differentiation
glomerulus development
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
spleen development
embryonic digestive tract morphogenesis
reproductive structure development
gland development
Sertoli cell differentiation
palate development
lung morphogenesis
lung vasculature development
bronchiole development
diaphragm development
respiratory system development
negative regulation of androgen receptor signaling pathway
metanephric mesenchymal cell differentiation
metanephric glomerular capillary formation
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
histone deacetylase binding
bHLH transcription factor binding
protein dimerization activity
androgen receptor binding
E-box binding
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