Keep as concentrated solution.
Predicted reactivity: Mouse (85%), Rat (82%).
Positive Control: Jurkat, NCI-H929, BCL-1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bHLHb21; Class B basic helix-loop-helix protein 21; helix-loop-helix protein HE47; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; MGC129647; MGC129648; negative vitamin D response element-binding protein; NOL1-TCF3 fusion; TCF-3; Transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); transcription factor 3 variant 3; Transcription factor A1; Transcription factor E2-alpha; transcription factor E2a; Transcription factor ITF-1; VDR interacting repressor; vitamin D receptor-interacting repressor
Gene Aliases: A1; AA408400; AGM8; ALF2; AW209082; BHLHB21; E12; E12/E47; E2A; E47; ITF1; ME2; Pan1; Pan2; TCF-3; TCF3; Tcfe2a; VDIR