This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
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Protein Aliases: HMG box transcription factor 3; T-cell factor 3; TCF-3; transcription factor 3; Transcription factor 7-like 1; transcription factor 7-like 1 (T-cell specific, HMG box); transcription factor 7-like 1 (T-cell specific, HMG-box); transcription factor 7-like 2 (T-cell specific, HMG box)
Gene Aliases: bHLHb21; TCF-3; TCF3; TCF7L1
Molecular Function: nucleic acid binding